Hardcover, 2011. Collects 1988's UNCANNY X-MEN #235 - 238 and 1990's UNCANNY X-MEN #270 - 272, NEW MUTANTS #95 - 97, & X-FACTOR #60 - 62.
Following from "Mutant Massacre", "Fall of the Mutants", and "Inferno", "X-Tinction Agenda" marks the fourth X-universe crossover, and has the notoriety of being the first such event of the nineties. But unlike the majority of those nineties events, this one comes from the pens of Chris Claremont and Louise Simonson -- both with one foot out the door of the X-franchise at this point, whether they realize it or not.
But before the crossover proper, the X-TINCTION AGENDA hardcover begins with UNCANNY X-MEN issues 235 - 238. Written by Claremont and illustrated by Marc Silvestri and Rick Leonardi, this storyline introduces the X-Men to the small island nation of Genosha, a technologically advanced paradise built on the backs of enslaved mutates. Claremont uses this 1988 tale as a metaphor for Apartheid, hitting on some heavy themes while never forgetting that X-MEN is, first and foremost, an action-adventure serial. It's generally regarded as one of the high points of his long run on the series, and its presence here, as a thematic companion to the main crossover, is appreciated -- though for the completionists out there, its inclusion was rendered moot in late 2014 with the publication of the X-MEN: INFERNO PROLOGUE collection.